L-arginineL-arginine – Natural form of arginineis an amino acid that is essential for the production of nitric oxide (NO) in the body. Nitric oxide is an important factor in the regulation of blood pressure.

L-arginine is also involved in many other important biochemical processes. None of this amino acid can seriously disrupt.

L-arginine occurs naturally in the human body. It is an amino acid endogenous – therefore one that can be produced by the body from other compounds.

Theoretically, the body does not need a supply of this amino acid from the food. Unfortunately, as research has shown, with age the ability to synthesize arginine in the human body begins to decrease.

Arginine deficiency and lead to an imbalance inside the body. Proper supplementation restores the appropriate level of the amino acid, which is important because of its vital functions.

An important supplement L-arginine is L-citrulline. This amino acid is involved in the same biochemical cycle, and its supplementation increases the level of l-arginine in blood for hours.


L-arginine – possible interactions

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  • Anticoagulants and anti-platelet drugs, herbs and supplements. These types of drugs, herbs and supplements reduce blood clotting. Taking L-arginine with them might increase the risk of bleeding.
  • Blood pressure drugs, herbs and supplements. L-arginine might reduce blood pressure in people who have high blood pressure. Combining use of L-arginine with a blood pressure drug, herb or supplement might increase the risk of blood pressure becoming too low.
  • Diabetes drugs, herbs and supplements. L-arginine might decrease blood sugar levels in people with diabetes. If you’re taking diabetes drugs, herbs or supplements, your dosage might need to be adjusted.
  • Sildenafil (Viagra). Use of this erectile dysfunction medication with L-arginine might cause your blood pressure to become too low.
  • Isoproterenol. Use of this heart medication with L-arginine might cause your blood pressure to become too low.
  • Nitrates. Use of this chest pain medication with L-arginine might cause your blood pressure to become too low.
  • Water pills (potassium-sparing diuretics). Don’t take amiloride (Midamor), spironolactone (Aldactone) or triamterene (Dyrenium) with L-arginine. These medications can increase potassium levels, increasing the risk of developing a higher than normal level of potassium in your blood (hyperkalemia).

L-arginine can worsen allergies or asthma. Use the supplement with caution if you have these conditions.

Be careful about taking L-arginine if you’ve had cold sores or genital herpes. Too much L-arginine in your system can potentially trigger the virus that causes those conditions.

L-arginine isn’t recommended (directly) after a heart attack due to concerns that the supplement might increase the risk of death.

Source: https://www.mayoclinic.org/drugs-supplements-l-arginine/art-20364681


ProArgi-9+ in the Physicians’ Desk Reference

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Since 1947, medical specialists across the world have turned to the Physician’s Desk Reference (PDR) as the authoritative source of information on drugs and prescribed substances. Synergy is pleased to note that ProArgi-9+ has been featured in the PDR, starting with the 2014 edition, as this expands the possibilities for people to discover the tremendous benefits of our flagship product.

Found in virtually every physician’s office, pharmacy, clinic and library, no medical reference is more current, more recognized, or more respected. Convenient digital versions of the PDR have also been recently made available. Both the physical and digital versions contain ProArgi-9+ label information, dosage instructions, images and more. We are confident that this will encourage more patients, medical professionals and students to discover and share ProArgi-9+ for its great value in supporting a healthy lifestyle.

source: synergyworldwide.com


L-Arginine and Alzheimer’s Disease

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L-arginine is an essential amino acid, involved in diverse physiological and pathological processes, including neurotransmission, neurogenesis and neuroplasticity, cellular redox metabolism and redox stress, inflammation, and regulation of cerebral blood flow. Increasing evidence implicates L-arginine in the pathogenesis of diverse age-related diseases, including Alzheimer’s disease. Understanding of the precise biochemical roles of L-arg will aid to rational development of therapeutic agents for various relevant human diseases intervention.

Jing Yi, Laura L. Horky, Avi L. Friedlich, Ying Shi, Jack T. Rogers and Xudong Huang

Int J Clin Exp Pathol (2009) 3, 211-238


Anti-aging effects of l-arginine

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l-Arginine is one of the most metabolically versatile amino acids. In addition to its role in the
synthesis of nitric oxide, l-arginine serves as a precursor for the synthesis of polyamines, proline, glutamate, creatine, agmatine and urea. Several human and experimental animal studies have indicated that exogenous l-arginine intake has multiple beneficial pharmacological effects when taken in doses larger than normal dietary consumption. Such effects include reduction in the risk of vascular and heart diseases, reduction in erectile dysfunction, improvement in immune response and inhibition of gastric hyperacidity. This review summarises several positive studies and personal experiences of l-arginine. The demonstrated anti-aging benefits of l-arginine show greater potential than any pharmaceutical or nutraceutical agent ever previously discovered.

Mohamed Z. Gad

© 2010 Cairo University. All rights reserved.

read more …


L-Arginine – dosing

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The following doses of l-arginine have been studied in scientific research:

By mouth:

  • Congestive heart failure: doses range from 6-20 grams per day, as three divided doses.
  • Organic erectile dysfunction (ED): 5 grams per day. Taking lower doses might not be effective.
  • Preventing inflammation of the digestive tract in premature infants: 260 mg/kg added to oral feedings daily for the first 30 days of life.
  • Chest pain associated with coronary artery disease (angina pectoris): 3-6 grams three times per day for up to one month.
  • Preventing the loss of the effectiveness of nitroglycerin in relieving pain in people with chest pain due to coronary artery disease: 700 mg four times daily.

L-arginine is possibly effective for…

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Chest pain (angina)

Taking L-arginine seems to decrease symptoms and improve exercise tolerance and quality of life in people with angina. However, L-arginine does not seem to improve the disease itself.


Erectile dysfunction (ED)

Taking 5 grams of L-arginine by mouth daily seems to improve sexual function in men with ED. Taking lower doses might not be effective.


High blood pressure

There is early evidence that taking L-arginine by mouth can reduce blood pressure in healthy people, people with high blood pressure, and people with slightly high blood pressure with or without diabetes.


Inflammation of the digestive tract in premature infants

Adding L-arginine to formula seems to prevent inflammation of the digestive tract in premature infants.


Nitrate tolerance

Taking 700 mg of L-arginine four times daily seems to prevent nitrate tolerance in people taking nitroglycerin for chest pain (angina pectoris).


Leg pain associated with poor blood flow (peripheral arterial disease)

Research suggests that taking L-arginine by mouth or intravenously (by IV) for up to 8 weeks increases blood flow in people with peripheral arterial disease.


Improving recovery after surgery

Taking L-arginine with ribonucleic acid (RNA) and eicosapentaenoic acid (EPA) before surgery or afterwards seems to help reduce the recovery time, reduce the number of infections, and improve wound healing after surgery.


High blood pressure during pregnancy (pre-eclampsia)

Although there are inconsistent results about the effects of L-arginine on pre-eclampsia, most research suggests that it can reduce blood pressure in women with this condition.

Source: medlineplus.gov



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  • Arginine, especially the form of HCL, reduces the viscosity of blood platelets, so it can strengthen today anticoagulants. The optional supplementation so you should consult with your doctor.
  • Arginine should not be used after acute myocardial infarction.
  • According to some sources, arginine should not be used in people prone to herpes.
  • Arginine should not take pregnant women, breastfeeding women and people with schizophrenia.
  • Arginine can not be used without consulting a medical person with cancer. Doses less than 6 grams of pure arginine per day are not taken into account as a potential problem for people with cancer, but for safety reasons the use of the presence of any cancer is contraindicated without medical permission.
  • Do not take arginine and lysine, because these two amino acids compete with one another, limiting their performance.
  • No dietary supplement can not be used continuously as a substitute for a varied diet.

AAKG and other forms of arginine

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Arginine meet sometimes in the form of “AAKG”, especially as a supplement or an ingredient supplements for athletes. L-arginine is a free, natural form of the amino acid and AAKG a molecule consisting of arginine and alpha-ketoglutaric acid. In other words, it arginine + AKG (keto acid, glutaric acid derivative). AAKG form is more stable after digestion as well as more effective, but it is an artificial creation. Other frequently used in suplementch forms of arginine is arginine hydrochloride (well soluble in water, but cheap b. A bitter and average absorbed) and arginine malate (well bioavailable, easily absorbed, acting quickly, but briefly).


Main interactions with drugs

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  • Arginine may cause low blood pressure. Caution is advised in people taking herbs or supplements that lower blood pressure.
  • May increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants (blood thinners) such as warfarin or heparin, antiplatelet drugs such as clopidogrel, and nonsteroidal anti-inflammatory drugs such as ibuprofen or naproxen.
  • May change blood sugar levels. Caution is advised when using medications that may affect blood sugar levels. People taking insulin or drugs for diabetes by mouth should be monitored closely by a qualified healthcare professional, including a pharmacist. Medication adjustments may be necessary.