L-arginine is an essential amino acid, involved in diverse physiological and pathological processes, including neurotransmission, neurogenesis and neuroplasticity, cellular redox metabolism and redox stress, inflammation, and regulation of cerebral blood flow. Increasing evidence implicates L-arginine in the pathogenesis of diverse age-related diseases, including Alzheimer’s disease. Understanding of the precise biochemical roles of L-arg will aid to rational development of therapeutic agents for various relevant human diseases intervention.
Jing Yi, Laura L. Horky, Avi L. Friedlich, Ying Shi, Jack T. Rogers and Xudong Huang
Int J Clin Exp Pathol (2009) 3, 211-238