Arginine deficiency can sometimes be dangerous for our body, because from a certain age, when the ability to synthesize arginine decreases, consider its supplementation. In acute shortage of arginine may experience muscle atrophy, decreased muscle strength, inhibition of growth and development as well as overweight and even obese. Other possible effects of arginine deficiency is repeated swelling, elevated blood pressure, impaired wound healing (impaired tissue regeneration), lipid disorders, and insulin secretion. Sometimes a failure and liver injury induced by toxins. Arginine is involved in many important, complex processes of life, and therefore it is difficult to mention all the possible consequences of its chronic shortages.